Homologous recombination DNA repair deficiency (HRD) is a therapeutic biomarker for sensitivity to platinum and poly(ADP-ribose) polymerase inhibitor therapies in breast and ovarian cancers. Several ...
Meiotic recombination generates genetic diversity and promotes proper chromosomal segregation of parental chromosomes. This process requires a set of recombinases polymerized on single-stranded (ss) ...
Tokyo, Japan – Researchers from Tokyo Metropolitan University have been studying DNA repair by homologous recombination, where the RecA protein repairs breaks in double-stranded DNA by incorporating a ...
Scientists at deCODE genetics/Amgen have constructed a complete map of how human DNA is mixed as it is passed down during reproduction. The map marks a major step in the understanding of genetic ...
A recent study, undertaken by researchers at the Tokyo Metropolitan University and the Tokyo Metropolitan Institute of Medical Science (both Japan), unravels key steps in the process of homologous ...
The present theory offers a unified solution to three closely related evolutionary problems. (1) Why does an evolving population explore only a small fraction of the accessible pathways in genotype ...
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